04/20|Claire and Evan both passed their prelims and Shubham joins the lab!
Congrats to these two as they advance to candidacy! We also had a new grad student join this semester. Welcome Shubham!
011/19|Karthik, Evan, and Runrun attend the 2019 EverythingBioSAXS workshop at APS!
This workshop provides an introduction to "everything" about small angle X-ray scattering for biomolecules. This 5th annual workshop offers insight into the theory and practice....more.
08/19|We're awarded our second RO1 and Karl joins the lab!
We have received our second R01 from NIH/NIGMS to study the mechanism of OMP biogenesis by the BAM complex! Our goal is to use biochemical techniques to.... more.
Mackie, B, Chen, D, Dong, D, Dong, C, Parker, H, Tooley, C, Noinaj, N, Min, Jinrong, and Huang, R. (2020). J. Med. Chem. Just Accepted Manuscripts. DOI: 10.1021/acs.jmedchem.0c00689
Chen, D, Dong, C, Dong, G, Srinivasan, K, Min, J, Noinaj, N, and Huang R. (2020). Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogues. J. Med. Chem. Article ASAP. DOI: 10.1021/acs.jmedchem.0c00770
Kammerman, M, Bera, A, Wu, R, Harrison, S, Maxwell, N, Lundquist, K, Noinaj, N, Chazin, W, and Cornelissen, C. (2020). Molecular Insight Into TdfH-Mediated Zinc Piracy From Human Calprotectin by Neisseria Gonorrhoeae. mBio. 11(3). e00949-20. DOI: 10.1128/mBio.00949-20
Yadav, R, Noinaj, N, Ostan, N, Moraes, T, Stoudenmore, J, Maurakis, S, & Cornelissen, CN. (2020). Structural Basis for Evasion of Nutritional Immunity by the Pathogenic Neisseriae. Front Microbiol, 10(2981).
Celia, H, Noinaj, N, and Buchanon, SK. (2020). Structure and Stoichiometry of the Ton Molecular Motor. Int Jmol Sci, 21(2), E375.
Chen, D, Linjie, L, Diaz, K, Iyamu, Iredia, D. Yadav, R. Noinaj N, Huang, R. (2019). Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for Nicotinamide N-Methyltransferase. J Med Chem, 62(23), 10783-10797. DOI: 10.1021/acs.jmedchem.9b01255
Imai, Y., Meyer, K. J., Iinishi, A., Favre-Godal, Q., Green, R., Manuse, S., … Lewis, K. (2019). A new antibiotic selectively kills Gram-negative pathogens. Nature, 576, 459–464. DOI: 10.1038/s41586-019-1791-1
Wu, R. Stephenson, R. Gichaba, A. & Noinaj, N. (2019). The big BAM theory: An open and closed case? Biochimica et Biophysica Acta (BBA) - Biomembranes, 183062. DOI: 10.1016/j.bbamem.2019.183062
Chen, D, Dong, G, Noinaj, N, Huang, R. (2019) Discovery of Bisubstrate Inhibitors for Protein N-Terminal Methyltransferase 1. J Med Chem, 62(7):3773-3779. DOI: 10.1021/acs.jmedchem.9b00206